This video is a recording of a presentation by Natasa Milic-Frayling given during the session on “Long-term digital data management and GxP compliance” at the International QA Conference 2021. The presentation focuses on practical aspects of implementing OECD guidance (released 20 Sept 2021) on long-term archive readability (section 6.16 Archive) that involves maintenance of legacy software in virtual environments. Natasa demonstrates the use of virtualized software through secure virtual desktops to support reconstruction of research studies that are decades old.